Beilstein J. Nanotechnol.2020,11, 1381–1393, doi:10.3762/bjnano.11.122
transient glutamate biocoating can be useful for multifunctional theranostics.
Keywords: blood plasma; brainnerveterminals; glutamate biocoating; maghemite (γ-Fe2O3) nanoparticles; protein biocorona; Introduction
Glutamate is a main fast excitatory neurotransmitter in the central nervous system. Normal
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Figure 1:
TEM micrograph of γ-Fe2O3 nanoparticles.
Beilstein J. Nanotechnol.2014,5, 778–788, doi:10.3762/bjnano.5.90
of Kyiv, 64 Volodymyrska Str, Kiev, Ukraine The Department of Polymer Particles, Institute of Macromolecular Chemistry AS CR, Heyrovsky Sq. 2, 162 06 Prague 6, Czech Republic 10.3762/bjnano.5.90 Abstract The manipulation of brainnerveterminals by an external magnetic field promises breakthroughs
characteristics of the glutamatergic neurotransmission were analysed. Using radiolabeled L-[14C]glutamate, it was shown that D-mannose-coated γ-Fe2O3 nanoparticles did not affect high-affinity Na+-dependent uptake, tonic release and the extracellular level of L-[14C]glutamate in isolated rat brainnerveterminals
nanoparticles (250 µg/mL) moved to an area, in which the magnet (250 mT, gradient 5.5 Т/m) was applied compared to 33.5 ± 3.0% of the control and 48.6 ± 3.0% of samples that were treated with uncoated nanoparticles. Therefore, isolated brainnerveterminals can be easily manipulated by an external magnetic
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Figure 1:
Transmission electron micrographs of (a) neat and (b) D-mannose-coated γ-Fe2O3 nanoparticles.